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Clomid ( clomiphene citrate ) was first synthesized in 1956 and introduced for clinical trials in 1960. Since then, Clomid has been widely used as a "first line" treatment to induce and regulate ovulation. Clomid is typically administered on either day's three to seven or day's five to nine of the menstrual cycle with "day one" defined as the first day of normal menstrual flow.

Clomid works at the hypothalamus, a small gland at the base of the brain. Clomid stimulates the production of gonadotropin releasing hormone ( GnRH ), which stimulates the pituitary gland to produce follicle stimulating hormone ( FSH ). FSH stimulates the development of the ovarian follicles which contain the eggs.

Clomid is taken orally and should be taken at the same time each day. The "fertile time," or the time of ovulation usually occurs five to eight days after the last Clomid tablet is taken. Sometimes Clomid is given to stimulate ovulation for intrauterine insemination, IUI, usually in combination with FSH.

Clomiphene is used for:

Treating female infertility and forcertain conditions as determined by your doctor.

Clomiphene is an ovulatory stimulant. It works by helping to produce more hormones that cause your ovaries to release 1 or more eggs.
Do NOT use Clomiphene if:

* you are allergic to any ingredient in Clomiphene
* you are pregnant
* you have abnormal vaginal bleeding
* you have ovarian cysts (small growths on the ovaries) or enlargement not due to polycystic ovarian syndrome
* you have or have ever had blockage of blood vessels (blood clots) in the legs, lungs, or other parts of the body
* you have liver problems, uncontrolled thyroid or adrenal gland problems, or a brain lesion (eg, pituitary gland tumor)

Contact your doctor or health care provider right away if any of these apply to you.
Before using Clomiphene :

Some medical conditions may interact with Clomiphene. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

* if you are planning to become pregnant or are breast-feeding
* if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
* if you have allergies to medicines, foods, or other substances
* if you have depression, endometriosis, polycystic ovarian syndrome, or uterine fibroids

Some MEDICINES MAY INTERACT with Clomiphene. However, no specific interactions with Clomiphene are known at this time.

What is the success rate?

Most couples are interested in two success statistics: the ovulation rate and the pregnancy rate. Fertility drugs are quite successful at stimulating ovulation: about 70 per cent of women will ovulate, the majority within the first three months of treatment. Of those who ovulate, 15 to 50 per cent will become pregnant.

The wide range in success rates is due to all the other factors affecting pregnancy, including the time in your cycle you have sex, your age and weight, and the speed and motility of your partner's sperm.

Are there any side effects?

Fertility drugs can cause a wide range of minor side effects, including mood swings, mild ovarian swelling, stomach pain, breast tenderness, insomnia, nausea and vomiting, blurred vision, headaches, fatigue, irritability, depression, weight gain and, in rarer cases, ovarian cysts.

It can also cause your cervical mucus to become drier, so you may want to use a vaginal lubricant that is sperm-friendly.

One study in the mid-1990s suggested that the risk of ovarian cancer in later life might be increased after more than 12 cycles of treatment. However, successive reviews and studies have failed to find a strong link between fertility drugs and ovarian cancer. Findings suggest that it is the infertility problem itself that may increase the risk, rather than the fertility drugs used to treat it.